ea0038fp2 | (1) | SFEBES2015
Kyle Catriona
, Upreti Rita
, Anderson Anna
, Chen Shaoyun
, Homer Natalie
, Andrew Ruth
, Stimson Roland
, Walker Brian
Human plasma contains both cortisol (F) and corticosterone (B). B has been largely neglected in humans as it is 1020 times less abundant however previous studies suggest B and F have differential tissue-specific actions. Compared with F, B has an enhanced response to ACTH, relatively higher concentrations in brain and CSF and differential transmembrane trafficking by ATP-binding cassette (ABC) transporters. Plasma F is bound to corticosteroid-binding globulin (CBG) and a...